The RaISE Trial: A feasibility RCT of Intermittent Theta Burst Stimulation for Young People with Anorexia Nervosa

Randomised Controlled Feasibility trial of Intermittent Theta Burst Stimulation for Young People with Anorexia Nervosa


Many people with anorexia nervosa find talking therapy helpful in their journey to recovery. But the effectiveness of therapy can vary from person to person, and some people with anorexia don’t find talking therapies as helpful.


Research shows that certain areas of the brain function differently when a person has anorexia, which can affect how someone processes feelings and what they find rewarding, as well as their mood, impulses, and choices. If we target this area of the brain using neuromodulation (i.e., brain-directed treatment) this could be helpful for people who did not find talking therapy as useful. For example, when our research group conducted a study with adults who had long-standing anorexia, we found that neuromodulation had positive effects on mood and food choice flexibility, followed by longer-term improvements in weight and eating disorder symptoms.


Intermittent theta burst stimulation (iTBS) is one type of neuromodulation we believe could be helpful for young people with anorexia. During iTBS, we hold a magnetic coil over an area of the brain that functions differently when someone has anorexia. The coil produces a sequence of pulses for 4 minutes, and these pulses travel through the scalp to activate brain cells underneath. TBS has not yet been used with young people who have anorexia, but evidence shows it is safe and effective for treating depression in young people.


To investigate whether TBS is helpful for young people with anorexia, the RaISE study is recruiting participants to receive 20-sessions of real OR fake TBS over four weeks. We need to include a fake or “placebo” group because people sometimes show improvements even when they are given a fake treatment, which is called the placebo effect. By comparing people’s responses to the real TBS and to the fake TBS, we can see whether the real TBS is actually more effective than fake TBS. Those receiving the fake treatment will be offered a full course of the real iTBS after the study.


To be eligible to participate in RaISE, you must:

·      Be aged between 13-30

·      Have a diagnosis of anorexia nervosa

·      Have undergone at least one full course of standard eating disorder treatment for anorexia nervosa, e.g., family-based therapy, in-patient treatment

·      Have a BMI over 14 (for participants over the age of 18) or over 66% of the median BMI for age and gender (for participants under the age of 18) 

·      Have approval from your eating disorder clinician if you have one

·      Use and understand English as a language for everyday conversation


To find out more, download our participant information sheets here:

Participant Information Sheet for Adults

Participant Information Sheet for Adolescents (under 16)

Participant Information Sheet for Parents / Carers

If you'd like to participate, contact one of our researchers to discuss the study further:

Keep updated by following our twitter @EDIFYresearch and Instagram @edifyresearch. If you have any questions, contact the research team at

This video was created in collaboration with four experts-by-experience, Isabel Jackson, and EDIFY youth advisors Isabella Malvisi, Katie McKenzie and Lucy Zocek. Videography by Jack Stonebridge

More research participation

[RECRUITMENT CLOSED] FREED-Mobile (FREED-M) study: Research Volunteers Wanted!

Do you have problems with your eating behaviours or concerns about your weight? Are you unsure whether you need help? We are exploring if the use of online resources are helpful for young people in deciding whether to seek support for their eating problem

Find out more

2-year Research Fellow job opportunity: UCL [POSITION FILLED]

University College London is looking to appoint a research associate to join the EDIFY project, to lead on data analysis of cohort studies exploring risk and resilience factors for the development of eating disorders.

Find out more

Research Participants Needed!

Survey of people with eating disorders on the cost-of-living crisis, food insecurity and poverty: Can you help us understand how people with eating disorders experience the ongoing cost-of-living crisis in the UK?

Find out more

We want to hear your STORY – Join our new research study!

Are you between 16 and 25 years old and have an eating disorder or think you may have one? Then we invite you to take part in a 12-month-long study that explores the diverse experiences of young people with eating disorders and how they recover from them.

Find out more

Turning points in eating disorders recovery among diverse individuals/ carers using adapted photovoice

We would like to hear from you if you would like to share the turning points or periods in you or your loved one's recovery, and if there is any significant person/place/object associated with that period.

Find out more

LENS: Lived Experiences Narratives and Scenarios of Eating Disorders

Are you aged 16-25 and have experience of eating disorder or disordered eating? We are keen to hear from young people with different experiences!

Find out more

[CALL CLOSED] Call for Artists in Residence

We are recruiting artists-in-residence to work with us

Find out more

Communicating about eating disorders online

We are keen to hear from young people with different experiences of posting or viewing posts about eating disorders on social media.

Find out more

Express your Experiences of Eating Disorders or Disordered Eating

For a research study at the University of Nottingham (part of the EDIFY study) please share with us your own unique experience expressed in any way you want.

Find out more
Need help, support or info?

Need help, support or info?

The sooner you seek support, the sooner things can start to get better. We can help you find the right option for you.